產(chǎn)品英文名稱：StemRD W3A-M-100 WNT-3a,Mouse,100ug
產(chǎn)品中文名稱：StemRD W3A-M-100 小鼠WNT-3a 蛋白因子，100ug

StemRD W3A-M-100 WNT-3a,Mouse,100ug 產(chǎn)品簡(jiǎn)介
wnt通路是細(xì)胞增殖分化的關(guān)鍵調(diào)控環(huán)節(jié)， 在胚胎發(fā)育和腫瘤發(fā)生中起著重要作用。wnt途徑參與了基因表達(dá)調(diào)節(jié)、 細(xì)胞遷移粘附、細(xì)胞極化等過(guò)程，同時(shí)還與其它信號(hào)通路存在交叉協(xié)同。Wnt/β-catenin通路在進(jìn)化過(guò)程中高度保守，此通路的主要分子構(gòu)成及相關(guān)調(diào) 控機(jī)制已得到基本闡明。對(duì)神經(jīng)系統(tǒng)而言已有足夠證據(jù)顯示此通路參與了對(duì)神經(jīng)前體細(xì)胞增殖， 分化以及決定細(xì)胞命運(yùn)的調(diào)控。
Wnt-3a 干細(xì)胞生長(zhǎng)分化因子是Wnt基因家族中重要成員，zui近的一些研究發(fā)現(xiàn)， Wnt-3a 干細(xì)胞生長(zhǎng)分化因子信號(hào)蛋白對(duì)神經(jīng)干細(xì)胞的定向分化的調(diào)控作用表現(xiàn)的十分明顯。小鼠WNT-3a 干細(xì)胞生長(zhǎng)分化因子蛋白包含328個(gè)氨基酸。

StemRD W3A-M-100 小鼠WNT-3a 蛋白因子，100ug 產(chǎn)品特性
? StemRD W3A-M-100 小鼠WNT-3a 蛋白因子，100ug 干細(xì)胞生長(zhǎng)分化因子活性經(jīng)過(guò)NIH 3T3 細(xì)胞鑒定，純度高
? StemRD W3A-M-100 小鼠WNT-3a 蛋白因子，100ug干細(xì)胞生長(zhǎng)分化因子生物活性在NIH 3T3 細(xì)胞經(jīng)過(guò)TCF報(bào)告基因?qū)嶒?yàn)鑒定The EC50為 50–150 ng/ml
? StemRD W3A-M-100 小鼠WNT-3a 蛋白因子，100ug 干細(xì)胞生長(zhǎng)分化因子產(chǎn)品經(jīng)過(guò)SDS-PAGE 和HPLC雙層鑒定純度大于90%

StemRD W3A-M-100 WNT-3a,Mouse,100ug 保存方法
The lyophilized protein is stable for at least 6 months if stored at -80 degreeC. Reconstituted protein is stable for at least two weeks at 4 degree C, but should be stored in aliquots at -80 degree C for longer term. Avoid repeated freeze and thaw.

StemRD W3A-M-100 WNT-3a,Mouse,100ug 產(chǎn)品英文描述
WNT-3a is a member of the WNT family of signaling proteins that play a key role in embryonic development and the integrity of adult tissues. StemRD W3A-M-100 WNT-3a,Mouse,100ug is a prototypic canonical WNT that signals through the β-catenin pathway. The predicted size of mouse StemRD W3A-M-100 WNT-3a,Mouse,100ug is a monomeric protein containing 333 amino acid residues. Due to glycosylation, it migrates at an apparent molecular weight of 40 kDa by SDS-PAGE analysis under nonreducing conditions. StemRD’s product W3A-M-100 WNT-3a,Mouse,100ug is expressed from a mouse cell line overexpressing mouse WNT-3a. Purification is performed with a proprietary process that is distinct from the published method.
? StemRD W3A-M-100 WNT-3a,Mouse,100ug Purity: Greater than 90% as determined by SDS-PAGE analysis
? StemRD W3A-M-100 WNT-3a,Mouse,100ug Biological Activity: The activity was determined by using a TCF reporter gene assay in NIH3T3 cells. The EC50 ranges from 50 - 150 ng/ml. Country of Origin USA

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