產(chǎn)品信息 Wnt信號(hào)通路是一個(gè)復(fù)雜的蛋白質(zhì)作用網(wǎng)絡(luò),其功能zui常見于胚胎發(fā)育和癌癥,但也參與成年動(dòng)物的正常生理過程。Wnt信號(hào)通路包括許多可調(diào)控Wnt信號(hào)分子合成的蛋白質(zhì),它們與靶細(xì)胞上的受體相互作用,而靶細(xì)胞的生理反應(yīng)則來源于細(xì)胞和胞外Wnt配體的相互作用。 BIO (6-bromoindirubin-3'-oxime): a specific GSK3 kinase inhibitor. Inhibition of GSK3-beta results in activation of the canonical WNT pathway leading to the translocation of beta-catenin to the nucleus. This chemical compound from StemRD is 98.5% pure (HPLC). In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives EC50 of 5.0 micromolar. Purity: Greater than 98.5% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request. Biological Activity: In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives EC50 of 5.0 micromolar. 重慶市華雅干細(xì)胞技術(shù)有限公司 |