Catalogue Number : 05121-77 DescriptionThe OKT3 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction. The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and renal allograft rejection. CD3產(chǎn)品描述:OKT3單克隆抗體的特異性反應的CD3 / T淋巴細胞抗原受體復合物的ε鏈。CD3復合物含有γ,δ,和ε鏈,和它的TCR復雜的部分,由所有成熟T淋巴細胞和胸腺細胞系的表達。CD3增強的信號轉(zhuǎn)導的抗原識別。
PeproTech公司的BioGems產(chǎn)品OKT3抗體是一種免疫抑制,這已被證明是一種有效的治療劑,肝,心,腎移植排斥反應。 Additional Information Clone OKT3 Format: PE-Cy7 Applications FC Reactivity Human
Isotype: Mouse IgG2a, kappa Research Interest: Adaptive Immunity Cell Type: Treg cells, T Cells, NK and NKT Cells, Th17 cells Preperation: The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product. Formulation: Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. References: Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989. Adair, J. R., Athwal, D. S., Bodmer, M. W., Bright, S. M., Collins, A. M., Pulito, V. L., ... & Jolliffe, L. K. (1994). Humanization of the murine anti-human CD3 monoclonal antibody OKT3. Human Antibodies, 5(1), 41-47. Kap, Y. S., van Meurs, M., van Driel, N., Koopman, G., Melief, M. J., Brok, H. P., ... & A't Hart, B. (2009). A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates. Journal of Histochemistry & Cytochemistry, 57(12), 1159-1167. Anti-Human CD3 PE-Cy7 Technical Data Sheet Catalogue Number : 05121-77 RUO: For Research Use Only. Not for use in diagnostic procedures. Product Information Clone: OKT3 Format/Conjugate: PE-Cy7 Concentration: 5 uL (0.5 ug)/test Reactivity: Human Laser: Blue (488nm) Peak Emission: 785nm Peak Excitation: 496nm Filter: 780/60 Brightness (1=dim,5=brightest): 4 Isotype: Mouse IgG2a, kappa Formulation: Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. Storage: Product should be kept at 2-8°C and protected from prolonged exposure to light. Applications: FC Description The OKT3 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction. The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and renal allograft rejection. Preparation & Storage The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product. Application Notes The antibody has been analyzed for quality through the flow cytometric analysis of the relevant cell type. The antibody can be used at less than or equal to 5 μL per test. A test is the amount of antibody required to stain a cell sample in the final volume of 100 μL. 重慶市華雅干細胞技術(shù)有限公司代理的PeproTech公司旗下的BioGems產(chǎn)品,咨詢: : References 1.Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York 2. Knapp W;(1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989. 3. Adair, J. R., Athwal, D. S., Bodmer, M. W., Bright, S. M., Collins, A. M., Pulito, V. L., ... ; Jolliffe, L. K. (1994). Humanization of the murine anti-human CD3 monoclonal antibody OKT3.;Human Antibodies,;5(1), 41-47. 4. Kap, Y. S., van Meurs, M., van Driel, N., Koopman, G., Melief, M. J., Brok, H. P., ... ; A't Hart, B. (2009). A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates.;Journal of Histochemistry ; Cytochemistry,;57(12), 1159-1167. PeproTech公司旗下的BioGems產(chǎn)品的其他相關(guān)信息如下: Additional OKT3 Formats Cat.No. Format Starting From 貨號:05121-20 Purified 貨號:05121-25 SAFIRE Purified 貨號:05121-40 BG Violet 450 貨號:05121-60 PE 貨號:05121-80 APC 貨號:05121-50 FITC 貨號:05121-70 PerCP-Cy5.5 貨號:05121-77 PE-Cy7 |